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Haemophagocytic Syndrome
Medications for Hemophagocytic Lymphohistiocytosis
Other titles: Haemophagocytic Lymphohistiocytosis; Haemophagocytic Syndrome; Hemophagocytic Syndrome; HLH
Hemophagocytic lymphohistiocytosis (HLH) is a life threatening illness as a result of endothelial tissues of their immune system resulting in excessive inflammation, which leads to damage to organs and tissue notably the liver, skin, brain and bone marrow.
You will find two kinds of HLH, primary HLH and HLH. Primary HLH is an hereditary illness that is also called familial hemophagocytic lymphohistiocytosis (FHL). Acquired lymphohistiocytosis or secondary HLH occurs after a substantial reaction for example malignancy a systemic infection or immunodeficiency.
At the system when NK cells and the T cells function properly their job is to destroy infected or damaged cells within the human anatomy. But in HLH is a rise in T cells and a reduction in NK cell activity, with a resulting rise in cytokines. This induces inflammatory responses which leads in symptoms and organ damage and the broad tissue and a protracted macrophage activation.
Signs of HLH are usually fever, rash, enlarged lymph nodes, enlarged liver and spleen, swollen gums and gastrointestinal issues. In case HLH is untreated it can progress to multi-organ collapse. Therapy for HLH is aimed at reducing the inflammation that was life-threatening.
Drugs Used to Heal Hemophagocytic Lymphohistiocytosis
The following listing of medications have been somehow associated with, or utilized in the treatment of this particular condition.
| Drug title | Rx / OTC | Pregnancy | CSA | Alcohol | Reviews | Rating | Popularity |
|---|---|---|---|---|---|---|---|
| Gamifant | Rx | N | Add review | 0.0 | |||
Generic title: emapalumab systemic Drug course: selective immunosuppressants For customers: dosage, interactions, side effects For professionals: AHFS DI Monograph, Prescribing Information | |||||||
| emapalumab | Rx | N | Add review | 0.0 | |||
Generic title: emapalumab systemic Brand title: Gamifant Drug course: selective immunosuppressants For customers: dosage, interactions, For professionals: A-Z Drug Facts, AHFS DI Monograph | |||||||
Legend
| Rx | prescription-only |
|---|---|
| OTC | On The Counter |
| Rx/OTC | Prescription or Over the Counter |
| Away Prizes | This drug might well not be accepted by the FDA for the treatment of this particular condition. |
| Pregnancy Category | |
|---|---|
| A | Adequate and well-controlled studies have failed to present a risk to the fetus in the first trimester of pregnancy (and there`s no evidence of risk in later trimesters). |
| B | Animal reproduction studies have failed to show a risk to the fetus and there are no sufficient and well-controlled studies in elderly women. |
| C | Animal research studies have demonstrated a negative effect on the fetus and there are no sufficient and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |
| D | There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks. |
| X | Studies in animals or humans have demonstrated fetal abnormalities or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and also the risks involved in use in elderly women clearly outweigh potential benefits. |
| N | FDA has not classified this drug. |
| Controlled Substances Act (CSA) Schedule | |
|---|---|
| N | Is not subject to the Controlled Substances Act. |
| Inch | features a higher possibility of abuse. Has no accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision. |
| Two | features a higher possibility of abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Psychotherapy can cause severe emotional or physical dependency. |
| 3 | Has a potential for abuse less than individuals in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Psychotherapy can lead to moderate or low physical dependence or high psychological dependence. |
| 4 | features a minimal potential for abuse relative to individuals in schedule 3. It has a currently accepted medical use in treatment in the United States. Psychotherapy can lead to limited physical dependence or psychological dependence relative to individuals in schedule 3. |
| 5 | features a minimal potential for abuse relative to individuals in schedule 4. Has a currently accepted medical use in treatment in the United States. Psychotherapy can lead to limited physical dependence or psychological dependence. |
| Alcohol | |
|---|---|
| X | Interacts with Medication. |
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Further advice
Always ask your healthcare provider to be sure the information displayed on these pages pertains to your circumstances.
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